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. 2012 Apr;9(4):345-50.
doi: 10.1038/nmeth.1931.

Protein interaction data curation: the International Molecular Exchange (IMEx) consortium

Sandra Orchard  1 , Samuel Kerrien, Sara Abbani, Bruno Aranda, Jignesh Bhate, Shelby Bidwell, Alan Bridge, Leonardo Briganti, Fiona S L Brinkman, Gianni Cesareni, Andrew Chatr-aryamontri, Emilie Chautard, Carol Chen, Marine Dumousseau, Johannes Goll, Robert E W Hancock, Linda I Hannick, Igor Jurisica, Jyoti Khadake, David J Lynn, Usha Mahadevan, Livia Perfetto, Arathi Raghunath, Sylvie Ricard-Blum, Bernd Roechert, Lukasz Salwinski, Volker Stümpflen, Mike Tyers, Peter Uetz, Ioannis Xenarios, Henning Hermjakob
Affiliations

Protein interaction data curation: the International Molecular Exchange (IMEx) consortium

Sandra Orchard et al. Nat Methods. 2012 Apr.

Erratum in

  • Nat Methods. 2012 Jun;9(6):626. Brinkman, Fiona [corrected to Brinkman, Fiona S L]; Hancock, Robert [corrected to Hancock, Robert E W]

Abstract

The International Molecular Exchange (IMEx) consortium is an international collaboration between major public interaction data providers to share literature-curation efforts and make a nonredundant set of protein interactions available in a single search interface on a common website (http://www.imexconsortium.org/). Common curation rules have been developed, and a central registry is used to manage the selection of articles to enter into the dataset. We discuss the advantages of such a service to the user, our quality-control measures and our data-distribution practices.

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Figures

Figure 1
Figure 1. Overview of the IMEx dataset
(a) Interaction detection methods currently represented in the IMEx dataset. (b) Types of interaction data represented in the IMEx dataset. (c) The range of species for which data is available in the IMEx dataset. Data taken from December 2011
See this image and copyright information in PMC

References

    1. Bader GD, Cary MP, Sander C. Pathguide: a pathway resource list. Nucleic acids research. 2006;34:d504–d506. - PMC - PubMed

    1. Orchard, et al. The minimum information required for reporting a molecular interaction experiment (MIMIx) Nature Biotechnology. 2007;25:894–898. This reference outlines the information an author needs to include in a manuscript to allow successful curation by a database

    1. Orchard S, Hermjakob H. The HUPO proteomics standards initiative - easing communication and minimizing data loss in a changing world. Briefings in bioinformatics. 2008;9:166–173. - PubMed
    1. Alfarano C, et al. The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic acids research. 2006;33:d418–d424. - PMC - PubMed
    1. Xenarios I, et al. Nucleic acids research. 2002;30:303–305. - PMC - PubMed

Publication types