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Review
. 2012:740:639-61.
doi: 10.1007/978-94-007-2888-2_28.

The biology of protein kinase C

Lily Zeng  1 , Samuel V Webster, Philip M Newton
Affiliations
Review

The biology of protein kinase C

Lily Zeng et al. Adv Exp Med Biol. 2012.

Abstract

This review gives a basic introduction to the biology of protein kinase C, one of the first calcium-dependent kinases to be discovered. We review the structure and function of protein kinase C, along with some of the substrates of individual isoforms. We then review strategies for inhibiting PKC in experimental systems and finally discuss the therapeutic potential of targeting PKC. Each aspect is covered in summary, with links to detailed resources where appropriate.

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