Review
doi: 10.1007/978-94-007-2888-2_30.
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart
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- PMID: 22453965
- DOI: 10.1007/978-94-007-2888-2_30
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Review
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart
Adv Exp Med Biol.
2012.
Abstract
Aim of this review is to give an overview and discuss recent findings on the role of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart. Special attention is drawn to excitation-contraction coupling (ECC) and excitation-transcription coupling (ETC). Because CaMKII expression and activity are increased in cardiac hypertrophy, heart failure, and during arrhythmias both in animal models as well as in the human heart a clinical significance of CaMKII is implied.
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