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Review
. 2012:740:685-702.
doi: 10.1007/978-94-007-2888-2_30.

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart

Lars S Maier  1
Affiliations
Review

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart

Lars S Maier. Adv Exp Med Biol. 2012.

Abstract

Aim of this review is to give an overview and discuss recent findings on the role of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart. Special attention is drawn to excitation-contraction coupling (ECC) and excitation-transcription coupling (ETC). Because CaMKII expression and activity are increased in cardiac hypertrophy, heart failure, and during arrhythmias both in animal models as well as in the human heart a clinical significance of CaMKII is implied.

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