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. 2012 Mar 26;2(2):e000361.
doi: 10.1136/bmjopen-2011-000361. Print 2012.

Risk of developing disability in pre and post-multidrug therapy treatment among multibacillary leprosy: Agra MB Cohort study

Anil Kumar  1 , Anita Girdhar, Bhavneswar Kumar Girdhar
Affiliations

Risk of developing disability in pre and post-multidrug therapy treatment among multibacillary leprosy: Agra MB Cohort study

Anil Kumar et al. BMJ Open. .

Abstract

Objectives: If leprosy is a public health problem, it is due to the disabilities it causes. Surprisingly little is known about the risk of disabilities. Even now, mainly cross-sectional studies report disability prevalence. The present study aims to report the risk of disability in pre and post-WHO multidrug therapy (MDT) in multibacillary leprosy patients and to assess the extent of the incidence of disability.

Methods: The study design is prospective and the setting is an institutional field area. Patients were detected during 2001-6 field surveys. Of the 289 multibacillary patients, 146 completed the study. Both sexes were involved. The primary outcome planned was to study cure of disease, relapses and disability in patients receiving MDT. The secondary outcome was to measure reaction and default. Assessment was done clinically. Data have been analysed using SPSS software, logistic, survival analysis was performed and the χ(2) test of significance was used.

Results: An important risk factor was found to be three or more nerves involved with odds of 3.73 (1.24-11.2), and delay in treatment; 2.27 (1.04-4.96) at the pre-MDT stage and three or more nerves involved with odds of 2.81 (1.0-7.9) at the post-MDT stage. The incidence of disability was found to be 2.74/100 person-years; 2.69 in the MDT arm and 2.84 in defaulters, with slightly higher disability among early defaulters (3.08) than among late defaulters (2.30). The study suggests that the incidence of disability could be slightly higher if treatment is not completed.

Conclusion: Early treatment for leprosy is a must for reducing the risk of disability, and treatment delay would increase the risk of disability. It is important to note that the incidence of disability between defaulters and those completing treatment was not found to be significantly different.

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Conflict of interest statement

Competing interests: None.

Figures

Figure 1
Figure 1
Incidence of disability in multibacillary leprosy patients who completed treatment.
Figure 2
Figure 2
Risk of developing disability among multibacillary leprosy patients post-multidrug therapy by treatment compliance.
Figure 3
Figure 3
Risk of developing disability among multibacillary leprosy patients post-multidrug therapy.
Figure 4
Figure 4
Risk of developing disability among multibacillary leprosy patients who defaulted from multidrug therapy.
See this image and copyright information in PMC

References

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