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. 2012:2012:541650.
doi: 10.1155/2012/541650. Epub 2012 Feb 20.

Prognostic impacts of hypoxic markers in soft tissue sarcoma

Eivind Smeland  1 , Thomas K Kilvaer, Sveinung Sorbye, Andrej Valkov, Sigve Andersen, Roy M Bremnes, Lill-Tove Busund, Tom Donnem
Affiliations

Prognostic impacts of hypoxic markers in soft tissue sarcoma

Eivind Smeland et al. Sarcoma. 2012.

Abstract

Background. We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from 206 patients with non-GIST STS were obtained and tissue microarrays were constructed. Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers. Results. In univariate analyses, GLUT-1 (P < 0.001) and HIF-2α (P = 0.032) expression correlated significantly with a poor disease-specific survival (DSS). In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1-2.7, P = 0.021) was a significant independent prognostic indicator of poor DSS. Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS.

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Figures

Figure 1
Figure 1
Immunohistochemical analysis in non-GIST STS representing negative, and score 1–3 of CAIX, GLUT-1, HIF-1α, and HIF-2α. non-GIST STS: non-gastrointestinal stromal tumor soft-tissue sarcomas, CAIX: carbonic anhydrase IX, GLUT-1: glucose transporter-1, and HIF-1/2α: hypoxia induced factor 1/2α.
Figure 2
Figure 2
DSS curves according to GLUT-1 (a), HIF-1α (b), HIF-2α (c) and CAIX (d) expression in non-GIST STS. DSS: disease-specific survival, GLUT-1: glucose transporter-1, HIF-1/2α: hypoxia induced factor 1/2α, CAIX: carbonic anhydrase IX, and non-GIST STS: non-gastrointestinal stromal tumor soft tissue sarcomas.
See this image and copyright information in PMC

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