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. 1974 Feb;1(1):41-3.
doi: 10.1111/j.1365-2125.1974.tb00204.x.

The effect of age on the hydroxylation of amylobarbitone sodium in man

R E Irvine  1 , J Grove, P A Toseland, J R Trounce
Affiliations

The effect of age on the hydroxylation of amylobarbitone sodium in man

R E Irvine et al. Br J Clin Pharmacol. 1974 Feb.

Abstract

1 Following a single oral dose of amylobarbitone sodium it has been shown that a group of young subjects convert a higher proportion of the dose to 3'-hydroxyamylobarbitone than a group of elderly subjects. 2 Twenty-four hours after the administration of the drug, the mean plasma level of amylobarbitone in the elderly group is significantly higher than in the group of young subjects. 3 It is concluded that the rate of hydroxylation of amylobarbitone sodium decreases with age.

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References

    1. J Pharm Pharmacol. 1971 Dec;23(12):936-40 - PubMed
    1. Clin Chim Acta. 1970 Aug;29(2):253-60 - PubMed
    1. Br Med J. 1971 Sep 11;3(5775):607-9 - PubMed

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