Vitamin C improves the quality of somatic cell reprogramming
- PMID: 22456737
- DOI: 10.1038/ng.2222
Vitamin C improves the quality of somatic cell reprogramming
Abstract
The reprogramming of somatic cells to a pluripotent state is prone to errors that could hamper the use of this technology. A new study now shows that vitamin C enhances the quality of somatic cell reprogramming in mice, highlighting the possibility that further manipulation of culture conditions could improve this technology for regenerative medicine.
Comment on
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Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells.Nat Genet. 2012 Mar 4;44(4):398-405, S1-2. doi: 10.1038/ng.1110. Nat Genet. 2012. PMID: 22387999 Free PMC article.
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