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. 2012 May 15;205(10):1539-43.
doi: 10.1093/infdis/jis237. Epub 2012 Mar 28.

Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals

Monique van Velzen  1 , Freek B van Loenen, Roland J W Meesters, Miranda de Graaf, Lies Remeijer, Theo M Luider, Albert D M E Osterhaus, Georges M G M Verjans
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Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals

Monique van Velzen et al. J Infect Dis. .

Abstract

Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV(R)) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV(S)) and multiple phylogenetic-related minor ACV(S) and ACV(R) TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV(S) and ACV(R) latent HSV-1 in human TG.

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