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. 2012 Apr 18;104(8):581-9.
doi: 10.1093/jnci/djs145. Epub 2012 Mar 27.

Biological, clinical, and psychosocial correlates at the interface of cancer and aging research

William Dale  1 , Supriya G Mohile, Basil A Eldadah, Edward L Trimble, Richard L Schilsky, Harvey J Cohen, Hyman B Muss, Kenneth E Schmader, Betty Ferrell, Martine Extermann, Susan G Nayfield, Arti Hurria; Cancer and Aging Research Group
Affiliations

Biological, clinical, and psychosocial correlates at the interface of cancer and aging research

William Dale et al. J Natl Cancer Inst. .

Abstract

In September 2010, the Cancer and Aging Research Group, in collaboration with the National Cancer Institute and the National Institute on Aging, conducted the first of three planned conferences to discuss research methodology to generate the highest quality research in older adults with cancer and then disseminate these findings among those working in the fields of cancer and aging. Conference speakers discussed the current level of research evidence in geriatric oncology, outlined the current knowledge gaps, and put forth principles for research designs and strategies that would address these gaps within the next 10 years. It was agreed that future oncology research trials that enroll older adults should include: (1) improved standardized geriatric assessment of older oncology patients, (2) substantially enhanced biological assessment of older oncology patients, (3) specific trials for the most vulnerable and/or those older than 75 years, and (4) research infrastructure that specifically targets older adults and substantially strengthened geriatrics and oncology research collaborations. This initial conference laid the foundation for the next two meetings, which will address the research designs and collaborations needed to enhance therapeutic and intervention trials in older adults with cancer.

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Figures

Figure 1
Figure 1
Percentage of robust (0 of 5 deficits), pre-frail (1–2 of 5 deficits), and frail (3 or more deficits) older adults in three age groups and the quality of the evidence regarding appropriate cancer treatments by age. Based on data from Fried et al. (54).
See this image and copyright information in PMC

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