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. 2012:4:75-89.
doi: 10.2147/CMAR.S9660. Epub 2012 Mar 12.

Management of cutaneous T cell lymphoma: new and emerging targets and treatment options

Janet Y Li  1 , Steven Horwitz, Alison Moskowitz, Patricia L Myskowski, Melissa Pulitzer, Christiane Querfeld
Affiliations

Management of cutaneous T cell lymphoma: new and emerging targets and treatment options

Janet Y Li et al. Cancer Manag Res. 2012.

Abstract

Cutaneous T cell lymphomas (CTCL) clinically and biologically represent a heterogeneous group of non-Hodgkin lymphomas, with mycosis fungoides and Sézary syndrome being the most common subtypes. Over the last decade, new immunological and molecular pathways have been identified that not only influence CTCL phenotype and growth, but also provide targets for therapies and prognostication. This review will focus on recent advances in the development of therapeutic agents, including bortezomib, the histone deacetylase inhibitors (vorinostat and romidepsin), and pralatrexate in CTCL.

Keywords: bortezomib; cutaneous T cell lymphoma; histone deacetylase inhibitors; novel targets; pralatrexate.

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Figures

Figure 1
Figure 1
Patients with mycosis fungoides presenting with limited (A) patches/plaques typically involving the buttocks, and with disseminated (B) patches/plaques and tumors.
Figure 2
Figure 2
Patient with Sézary syndrome presenting clinically with generalized erythroderma and thickening (lichenification) of the skin.
See this image and copyright information in PMC

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