Stroke: Can PSD95 inhibitors widen the therapeutic window?

Comment

Alexandra Flemming. Nat Rev Drug Discov. 2012.

. 2012 Mar 30;11(4):272.

doi: 10.1038/nrd3716.

No abstract available

Comment on

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.
Bach A, Clausen BH, Møller M, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K. Bach A, et al. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3317-22. doi: 10.1073/pnas.1113761109. Epub 2012 Feb 17. Proc Natl Acad Sci U S A. 2012. PMID: 22343531 Free PMC article.
Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain.
Cook DJ, Teves L, Tymianski M. Cook DJ, et al. Nature. 2012 Feb 29;483(7388):213-7. doi: 10.1038/nature10841. Nature. 2012. PMID: 22388811