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Review
. 2012 Aug;33(6):916-22.
doi: 10.1007/s00246-012-0300-1. Epub 2012 Mar 30.

Optical mapping in the developing zebrafish heart

M Khaled Sabeh  1 , Hussein Kekhia, Calum A Macrae
Affiliations
Review

Optical mapping in the developing zebrafish heart

M Khaled Sabeh et al. Pediatr Cardiol. 2012 Aug.

Abstract

Understanding the developmental basis of cardiac electrical activity has proven technically challenging, largely as a result of the inaccessible nature of the heart during cardiogenesis in many organisms. The emergence of the zebrafish as a model organism has availed the very earliest stages of heart formation to experimental exploration. The zebrafish also offers a robust platform for genetic and chemical screening. These tools have been exploited in screens for modifiers of cardiac electrophysiologic phenotypes and in screens for novel drugs.

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