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. 2007 Jan;4(1):58-61.

Prevention of bisphosphonates-induced osteonecrosis

Anna Baraldi  1 , Vittorio Fusco, Alessandro Bellora, Massimo Pini
Affiliations

Prevention of bisphosphonates-induced osteonecrosis

Anna Baraldi et al. Clin Cases Miner Bone Metab. 2007 Jan.

Abstract

The osteonecrosis of the jaw is a new emergent disease, secondary to prolonged use of bisphosphonates. Bisphosphonates are a class of drug used in prevention and cure of bone diseases such as malignancy or bone metabolic diseases. In this article, we have tried to summarize, for patients taking IV or oral bisphosphonates-therapy, the most important informations on the pathogenesis and the risk factors in osteonecrosis of the jaw with particular attention about the preventive policies.

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References

    1. Marx RE. Pamidronate (Aredia)and zoledronate (Zometa) induced avascular necrosis of the jaw: a growing epidemic. J Oral Maxillofac Surg. 2003;61:1115–1118. - PubMed
    1. Migliorati CA. Bisphosphonates and oral cavity avascular bone necrosis. J Clin Oncol. 2003;21:4253–4254. - PubMed
    1. Ruggiero SL, Merhotra B, Rosemberg TJ, Engroff SL. Osteonecrosis of the jaw associated with use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004;62:527–534. - PubMed
    1. Marx RE, Sawatari Y, Fotin M, Broumand V. Bisphosphonates –Induced exposed bone (osteonecrosis /osteopetrosis) of the jaws: risk factors, recognition, prevention,and treatement. J Oral Maxillofac Surg. 2005;63:1567–1575. - PubMed
    1. Migliorati CA, Shubert MM, Peterson DE, Seneda LM. Bisphosphonates-associated osteonecrosis of mandibular and maxillary bone: an emerging oral complication of supportive cancer therapy. Cancer. 2005;104:83–84. - PubMed

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