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. 2012 Jul;55(1):e1-4.
doi: 10.1093/cid/cis343. Epub 2012 Mar 28.

Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms

Ana Treviño  1 , Mariola Lopez, Eugenia Vispo, Antonio Aguilera, Jose M Ramos, Rafael Benito, Lourdes Roc, Jose M Eiros, Carmen de Mendoza, Vincent Soriano; HTLV Spanish Study Group
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Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms

Ana Treviño et al. Clin Infect Dis. 2012 Jul.

Abstract

Interleukin 28B (IL28B) rs12979860 polymorphisms were examined in 41 individuals with human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis than in 29 asymptomatic carriers (80% vs 20%; P = .03), and median HTLV-1 proviral load was greater in CT/TT than CC carriers (P = .01). Thus, IL28B testing and closer follow-up of HTLV-1 asymptomatic CT/TT carriers is warranted.

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