Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Aug;11(4):359-66.
doi: 10.1007/BF02335938.

Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients

A Boiardi  1 , L Munari, A Silvani, C L Solero, E Bombardieri
Affiliations

Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients

A Boiardi et al. Ital J Neurol Sci. 1990 Aug.

Abstract

We studied the activity of two enzymes NSE and TK in the biological fluids of 104 patients with nervous system diseases, who fell into 4 groups. 20 subjects out of 35 in the tumor group had glial tumors. We fixed a cut-off value of NSE and TK activity at the 95th percentile of the control group, both in serum and in CSF. The aim of our investigation was to assess the reliability of TK and NSE assays in separating brain tumors from other neurological diseases. In our patients, most of the TK activity above the cut-off value was found in the tumor group. Serum TK seems to be a useful marker for following up cerebral tumors after surgery, but NSE is less useful for this purpose.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. J Neurosurg. 1985 Oct;63(4):568-72 - PubMed
    1. Lancet. 1981 Apr 11;1(8224):808-11 - PubMed
    1. J Neurol Sci. 1983 Aug-Sep;60(3):443-51 - PubMed
    1. Lancet. 1983 Aug 13;2(8346):361-3 - PubMed
    1. Arch Pathol Lab Med. 1984 Jul;108(7):536-40 - PubMed

MeSH terms

LinkOut - more resources