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. 2010 Jan;7(1):27-31.

Periprosthetic bone density as outcome of therapeutic response

Giovanni Iolascon  1 , Gioconda Di Pietro, Annarita Capaldo, Carmine Gioia, Salvatore Gatto, Francesca Gimigliano
Affiliations

Periprosthetic bone density as outcome of therapeutic response

Giovanni Iolascon et al. Clin Cases Miner Bone Metab. 2010 Jan.

Abstract

The bone surrounding a prosthetic implant normally experiences a progressive quantitative reduction as a result of stress shielding and wear debris production, that can lead to the aseptic loosening of the implant. Dual-energy X-ray absorptiometry (DXA), using software algorithms, can ensure a surrogate measure of load redistribution after the implant of the prosthetic components and can be a valid tool to evaluate the efficacy of pharmacological therapy to reduce the periprosthetic bone loss. In several animal and human studies DXA has been able to quantify antiresorptive action of bisphosphonates in the periprosthetic area.

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Figures

Figure 1
Figure 1
- Macrophage as the pivotal cell of wear debris induced inflammation.
Figure 2
Figure 2
- Seven Gruen zones in DXA periprosthetic evaluation.
See this image and copyright information in PMC

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