Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Mar 30;110(7):904-6.
doi: 10.1161/RES.0b013e31825332a3.

Epicardium-derived cardiac mesenchymal stem cells: expanding the outer limit of heart repair

Manvendra K Singh  1 , Jonathan A Epstein
Affiliations
Comment

Epicardium-derived cardiac mesenchymal stem cells: expanding the outer limit of heart repair

Manvendra K Singh et al. Circ Res. .

Abstract

The epicardium is derived from the proepicardial organ, a source of multipotent progenitor cells. Epicardium contribution to the developing coronary vasculature and to cardiac interstitial cells has been established. Studies over the past several years have suggested that epicardium-derived cells can adopt cardiomyocyte and vascular smooth muscle fates and can contribute to cardiac repair when activated by injury, . Recently, Chong et al have provided a detailed characterization of a population of epicardial–derived multipotent cardiac-progenitor cells (cardiac CFU-Fs). These cells, which do not arise from the bone marrow, neural crest or myocardium, resemble mesenchymal stem cells (MSCs) and may participate in cardiac development, homeostasis and repair.

PubMed Disclaimer

Comment on

  • Adult cardiac-resident MSC-like stem cells with a proepicardial origin.
    Chong JJ, Chandrakanthan V, Xaymardan M, Asli NS, Li J, Ahmed I, Heffernan C, Menon MK, Scarlett CJ, Rashidianfar A, Biben C, Zoellner H, Colvin EK, Pimanda JE, Biankin AV, Zhou B, Pu WT, Prall OW, Harvey RP. Chong JJ, et al. Cell Stem Cell. 2011 Dec 2;9(6):527-40. doi: 10.1016/j.stem.2011.10.002. Cell Stem Cell. 2011. PMID: 22136928 Free PMC article.

References

    1. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008;454:109–113 - PMC - PubMed
    1. Smart N, Bollini S, Dube KN, Vieira JM, Zhou B, Davidson S, Yellon D, Riegler J, Price AN, Lythgoe MF, Pu WT, Riley PR. De novo cardiomyocytes from within the activated adult heart after injury. Nature. 2011;474:640–644 - PMC - PubMed
    1. Chong JJ, Chandrakanthan V, Xaymardan M, Asli NS, Li J, Ahmed I, Heffernan C, Menon MK, Scarlett CJ, Rashidianfar A, Biben C, Zoellner H, Colvin EK, Pimanda JE, Biankin AV, Zhou B, Pu WT, Prall OW, Harvey RP. Adult cardiac-resident msc-like stem cells with a proepicardial origin. Cell Stem Cell. 2011;9:527–540 - PMC - PubMed
    1. Epstein JA. Franklin h. Epstein lecture. Cardiac development and implications for heart disease. N Engl J Med. 2010;363:1638–1647 - PubMed
    1. Gittenberger-de Groot AC, Vrancken Peeters MP, Mentink MM, Gourdie RG, Poelmann RE. Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions. Circ Res. 1998;82:1043–1052 - PubMed

Publication types