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. 2012:2012:642893.
doi: 10.1155/2012/642893. Epub 2012 Feb 7.

Effect of domperidone on insufficient lactation in puerperal women: a systematic review and meta-analysis of randomized controlled trials

Alla Osadchy  1 , Myla E Moretti, Gideon Koren
Affiliations

Effect of domperidone on insufficient lactation in puerperal women: a systematic review and meta-analysis of randomized controlled trials

Alla Osadchy et al. Obstet Gynecol Int. 2012.

Abstract

Background. There is a controversy within the medical community regarding the role of domperidone as a galactagogue and the drug has been removed from the US market owing to safety concerns. Objective. To perform a systematic review and meta-analysis of the available data assessing the effect of domperidone on breast milk production in women experiencing insufficient lactation. Study Selection. Randomized controlled trials (RCTs) examining the effect of domperidone on breast milk production of puerperal women were eligible for inclusion. Data Analysis. Absolute and relative changes from baseline were calculated for individual studies and pooled using a random effects model. Results. Three RCTs including 78 participants met the inclusion criteria. All showed a statistically significant increase in breast milk production following treatment with domperidone. The analysis of pooled data demonstrated a statistically significant relative increase of 74.72% (95% CI = 54.57; 94.86, P < 0.00001) in daily milk production with domperidone treatment compared to placebo. No maternal or neonatal adverse events were observed in any of the trials. Conclusions. Evidence from a few small RCTs of moderate to high quality suggests that domperidone produces a greater increase in breast milk supply than placebo.

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Figures

Figure 1
Figure 1
Flow chart of selected studies.
Figure 2
Figure 2
Percent change in milk volume with domperidone treatment.
See this image and copyright information in PMC

References

    1. Palda VA, Guise JM, Wathen CN, The Canadian Task Force on Preventive Health Care . CTFPHC Technical Report . #03-6. London, Ontario, Canada: Canadian Task Force; 2003. Interventions to promote breastfeeding: updated recommendations from the canadian task force on preventive health care.
    1. Chalmers B, Levitt C, Heaman M, O'Brien B, Sauve R, Kaczorowski J. Breastfeeding rates and hospital breastfeeding practices in Canada: a national survey of women. Birth. 2009;36(2):122–132. - PubMed
    1. Hurst NM. Recognizing and treating delayed or failed lactogenesis II. Journal of Midwifery and Women’s Health. 2007;52(6):588–594. - PubMed
    1. Zuppa AA, Sindico P, Orchi C, et al. Safety and efficacy of galactogogues: substances that induce, maintain and increase breast milk production. Journal of Pharmacy and Pharmaceutical Sciences. 2010;13(2):162–174. - PubMed
    1. Bunik M, Chantry CJ, Howard CR, et al. ABM clinical protocol #9: use of galactogogues in initiating or augmenting the rate of maternal milk secretion (First revision January 2011) Breastfeeding Medicine. 2011;6(1):41–49. - PubMed

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