Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012:2012:614781.
doi: 10.1155/2012/614781. Epub 2012 Jan 29.

Pretransplant fasting glucose predicts new-onset diabetes after liver transplantation

Elizabeth J Carey  1 , Bashar A Aqel, Thomas J Byrne, David D Douglas, Jorge Rakela, Hugo E Vargas, Adyr A Moss, David C Mulligan, K Sudhakar Reddy, Harini A Chakkera
Affiliations

Pretransplant fasting glucose predicts new-onset diabetes after liver transplantation

Elizabeth J Carey et al. J Transplant. 2012.

Abstract

New-onset diabetes after transplantation (NODAT) is common after liver transplant and associated with poorer outcomes. The aim of this study was to identify risk factors for NODAT in liver transplant recipients off corticosteroids. In 225 adult nondiabetic liver transplant recipients, the mean age was 51.7 years, the majority were men (71%), and half had HCV (49%). The mean calculated MELD score at transplantation was 18.7, and 19% underwent living-donor transplant (LDLT). One year after transplantation, 17% developed NODAT, and an additional 16% had impaired fasting glucose. The incidence of NODAT in patients with HCV was 26%. In multivariate analysis, HCV, pretransplant FPG, and LDLT were significant. Each 10 mg/dL increase in pretransplant FPG was associated with a twofold increase in future development of NODAT. The incidence of NODAT after liver transplant in patients off corticosteroids is 17%. Risk factors for developing NODAT include HCV and pretransplant FPG; LDLT is protective.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Incidence of NODAT by pretransplant fasting plasma glucose (N = 225).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. McGuire BM, Rosenthal P, Brown CC, et al. Long-term management of the liver transplant patient: recommendations for the primary care doctor: special feature. American Journal of Transplantation. 2009;9(9):1988–2003. - PubMed
    1. Marchetti P. New-onset diabetes after liver transplantation: from pathogenesis to management. Liver Transplantation. 2005;11(6):612–620. - PubMed
    1. Baid S, Cosimi AB, Farrell ML, et al. Posttransplant diabetes mellitus in liver transplant recipients: risk factors, temporal, relationship with hepatitis C virus allograft hepatitis, and impact on mortality. Transplantation. 2001;72(6):1066–1072. - PubMed
    1. Navasa M, Bustamante J, Marroni C, et al. Diabetes mellitus after liver transplantation: prevalence and predictive factors. Journal of Hepatology. 1996;25(1):64–71. - PubMed
    1. John PR, Thuluvath PJ. Outcome of patients with new-onset diabetes mellitus after liver transplantation compared with those without diabetes mellitus. Liver Transplantation. 2002;8(8):708–713. - PubMed

LinkOut - more resources