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. 2012 Mar 31:12:2.
doi: 10.1186/1472-6823-12-2.

The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis

M Hassan Murad  1 , Ahmad Hazem, Fernando Coto-Yglesias, Svitlana Dzyubak, Shabnum Gupta, Irina Bancos, Melanie A Lane, Patricia J Erwin, Lars Berglund, Tarig Elraiyah, Victor M Montori
Affiliations

The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis

M Hassan Murad et al. BMC Endocr Disord. .

Abstract

Background: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis.

Methods: We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data.

Results: 35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant.

Conclusions: The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.

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Figures

Figure 1
Figure 1
Study selection process.
Figure 2
Figure 2
Random effects meta-analysis (all-cause mortality).
Figure 3
Figure 3
Random effects meta-analysis (cardiovascular death).
Figure 4
Figure 4
Random effects meta-analysis (cardiac events).
Figure 5
Figure 5
Random effects meta-analysis (myocardial infarction).
See this image and copyright information in PMC

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