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Comment
. 2012 Mar 30;149(1):18-20.
doi: 10.1016/j.cell.2012.02.038.

The virtues of youth and maturity (in dentate granule cells)

Colin Lever  1 , Neil Burgess
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Free article
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The virtues of youth and maturity (in dentate granule cells)

Colin Lever et al. Cell. .
Free article

Abstract

How does adult neurogenesis contribute to memory? Nakashiba and colleagues generated mutant mice in which synaptic output from older hippocampal granule cells was specifically blocked. Experiments with these mice reveal an unpredicted age-dependent specialization of function, demonstrating that recently born cells support pattern separation, whereas older cells support pattern completion.

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