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Comment
. 2012 Mar 30;45(6):708-9.
doi: 10.1016/j.molcel.2012.03.014.

R loops: lassoing DNA methylation at CpGi

Paula M Vertino  1 , Paul A Wade
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R loops: lassoing DNA methylation at CpGi

Paula M Vertino et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, Ginno et al. (2012) describe unusual sequence features at promoter CpG islands that can lead to formation of persistent RNA-DNA hybrids (R loops), which are proposed to prevent genomic DNA methylation.

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