Evolution and rebirth of functional stereotaxy in the subthalamus

Abstract

The first human stereotactic surgery based on intracerebral landmarks and Cartesian coordinates was performed in 1947. With this followed the publication of a number of stereotactic frames and atlases. The intercommissural line joining the anterior and posterior commissures was to define stereotactic coordinate systems used in movement disorders and other functional neurosurgical procedures. Initially the target for Parkinson disease was the globus pallidus internus (GPi), but many investigators soon turned to the thalamus or parts of the subthalamus, but not the subthalamic nucleus. Microelectrode recording was introduced in 1961. With the apparent clinical efficacy of L-DOPA in 1965 interest in stereotactic surgery for Parkinson disease declined. The failure of prolonged, consistent pharmacologic management of bradykinesia and tremor, the side effects of dyskinesias, and the fading therapeutic success of medical treatment of movement disorders led to a resurgence of interest in the surgical management of movement disorders. With advances in understanding of the functional anatomy of the corticobasal ganglia circuit, advances in brain imaging, more sophisticated electrophysiologic recordings, and the use of deep brain stimulation as a reversible lesion, stereotactic surgery returned as a viable option for the treatment of movement disorders. The posterior medial part of the globus pallidus, ventral intermediate nucleus of the thalamus, and the subthalamus, its nuclei and pathways, are sites for interrupting pathophysiologic circuits. Not only has this been applied to movement disorders, but to epilepsy, chronic pain, and behavioral disorders.

Keywords: Behavioral disorders; Chronic pain; DBS; Deep brain stimulation; EEG; Electroencephalography, electroencephalogram; Epilepsy; Functional stereotaxy; GPe; GPi; Globus pallidus externus; Globus pallidus internus; MRI; Magnetic resonance imaging; Movement disorders; OCD; Obsessive-compulsive disorder; PPN; Pedunculopontine nucleus; SNr; STN; Substantia nigra pars reticularis; Subthalamic nucleus; Subthalamus (ventral thalamus); VL; VPM; Ventral intermediate nucleus; Ventral lateral nucleus; Ventral posterior medial nucleus; Vim; ZI; Zona incerta.