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. 2011:36:287-329.
doi: 10.1016/B978-0-12-387667-6.00008-7. Epub 2011 Jun 23.

Tadalafil

Alaa A-M Abdel-Aziz  1 , Yousif A Asiri, Adel S El-Azab, Mohamed A Al-Omar, Takehisa Kunieda
Affiliations

Tadalafil

Alaa A-M Abdel-Aziz et al. Profiles Drug Subst Excip Relat Methodol. 2011.

Abstract

Tadalafil is PDE5 inhibitor that has recently been approved for the treatment of ED. The mechanism of action of tadalafil is similar to sildenafil and vardenafil through the inhibition of PDE. In both chemical structure and PDE subtype selectivity profile, tadalafil differs markedly from sildenafil and vardenafil. Compared with sildenafil and vardenafil, tadalafil exhibits a prolonged plasma residence and window of therapeutic response. The physical properties, spectroscopic data and chromatographic methods of determination of tadalafil are documented.

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