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Comment
. 2012 Apr 2;14(4):339-41.
doi: 10.1038/ncb2476.

Signalling the end of the line

John van Tuyn, Peter D Adams
Comment

Signalling the end of the line

John van Tuyn et al. Nat Cell Biol. .

Abstract

Cellular senescence is a stable proliferation arrest induced by triggers such as short telomeres, activated oncogenes and genotoxic stress. Two studies show that cellular senescence induced by genotoxic stress depends on chronic DNA-damage signalling from irreparable damage to telomeres. Hence, dysfunctional or damaged telomeres are the initiators of multiple modes of senescence.

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