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. 2012 Jan;57(1):58-60.
doi: 10.4103/0019-5154.92683.

Multisystem Langerhans cell histiocytosis in adult

Anubhav Garg  1 , Pramod Kumar
Affiliations

Multisystem Langerhans cell histiocytosis in adult

Anubhav Garg et al. Indian J Dermatol. 2012 Jan.

Abstract

Langerhans cell histiocytosis (LCH), is a rare disorder, clinically presents with heterogeneous manifestations, and has an unpredictable outcome. Commonly seen in infancy or early childhood, the disorder is characterized by proliferation of abnormal and clonal Langerhans cell in skin, bone, lymph nodes, lungs, liver, spleen, and bone marrow. Occurrence of LCH in adults is rare. Here, we report the case of an adult with acute onset of polymorphic eruptions all over the body, which on biopsy showed features of multisystem LCH, and was confirmed by immunohistochemistry. Although multisystem LCH has a poor prognosis, our patient responded well to chemotherapy.

Keywords: Adult LCH; histiocytic infiltrate; langerhans cell histiocytosis.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Scaling with crusting present over face, mimicking seborrheic dermatitis
Figure 2
Figure 2
Yellow-brown papules with pustules present over chest
Figure 3
Figure 3
Ulcers present over lips
Figure 4
Figure 4
Diffuse histiocytic infiltrate, H and E staining, ×10
Figure 5
Figure 5
Histiocytic infiltrate, H and E staining, ×100
Figure 6
Figure 6
S-100 positive, ×100
See this image and copyright information in PMC

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