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Review
. 2012 Apr 24;51(16):3321-33.
doi: 10.1021/bi201215r. Epub 2012 Apr 10.

Architecture of the spliceosome

Clarisse van der Feltz  1 , Kelsey Anthony, Axel Brilot, Daniel A Pomeranz Krummel
Affiliations
Review

Architecture of the spliceosome

Clarisse van der Feltz et al. Biochemistry. .

Abstract

Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human U1 snRNP. This review provides an overview of our current understanding of the architecture of the spliceosome and the RNA-protein complexes integral to its function, the U snRNPs.

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