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. 2012 Apr 20;77(8):4143-7.
doi: 10.1021/jo3002535. Epub 2012 Apr 10.

Diastereo- and enantioselective [3 + 2] cycloaddition reaction of Morita-Baylis-Hillman carbonates of isatins with N-phenylmaleimide catalyzed by Me-DuPhos

Yan Wang  1 , Li Liu, Tao Zhang, Neng-Jun Zhong, Dong Wang, Yong-Jun Chen
Affiliations

Diastereo- and enantioselective [3 + 2] cycloaddition reaction of Morita-Baylis-Hillman carbonates of isatins with N-phenylmaleimide catalyzed by Me-DuPhos

Yan Wang et al. J Org Chem. .

Abstract

A Me-DuPhos-catalyzed efficient asymmetric [3 + 2] cycloaddition reaction between Morita-Baylis-Hillman carbonates of isatins and N-phenylmaleimide has been developed. This reaction constructs three chiral centers in one step to afford spirocyclopentaneoxindoles in good yields (up to 84%) with excellent diastereo- and enantioselectivies (up to 99% ee).

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