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Comparative Study
. 2012 Mar;28(3):247-50.
doi: 10.1089/aid.2011.0064. Epub 2011 Jul 8.

Fracture risk by HIV infection status in perinatally HIV-exposed children

George K Siberry  1 , Hong Li, Denise Jacobson; Pediatric AIDS Clinical Trials Group (PACTG) 219/219C Study
Affiliations
Comparative Study

Fracture risk by HIV infection status in perinatally HIV-exposed children

George K Siberry et al. AIDS Res Hum Retroviruses. 2012 Mar.

Abstract

The objective of this study was to examine the incidence of fractures in HIV-infected children and comparable HIV-exposed, uninfected (HEU) children in a multicenter, prospective cohort study (PACTG 219/219C) in the United States. The main outcome was first fracture during the risk period. Nine fractures occurred in 7 of 1326 HIV-infected and 2 of 649 HEU children, corresponding to incidence rates of 1.2 per 1000 person-years and 1.1 per 1000 person-years, respectively. The incidence rate ratio was 1.1 (95% CI 0.2, 5.5). There was no evidence of a substantially increased risk of fracture in HIV-infected compared to HEU children.

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