Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Apr 20;14(8):1974-7.
doi: 10.1021/ol300385k. Epub 2012 Apr 3.

Regioselective enzymatic carboxylation of phenols and hydroxystyrene derivatives

Christiane Wuensch  1 , Silvia M Glueck, Johannes Gross, Dominik Koszelewski, Markus Schober, Kurt Faber
Affiliations
Free PMC article

Regioselective enzymatic carboxylation of phenols and hydroxystyrene derivatives

Christiane Wuensch et al. Org Lett. .
Free PMC article

Abstract

The enzymatic carboxylation of phenol and styrene derivatives using (de)carboxylases in carbonate buffer proceeded in a highly regioselective fashion: Benzoic acid (de)carboxylases selectively formed o-hydroxybenzoic acid derivatives, phenolic acid (de)carboxylases selectively acted at the β-carbon atom of styrenes forming (E)-cinnamic acids.

PubMed Disclaimer

Figures

Scheme 1
Scheme 1. Regio-complementary Enzymatic Carboxylation of Phenols and Hydroxystyrene Derivatives
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. The major intermediates derived from crude oil encompass methanol, alkenes (ethene, propene, butene, butadiene), and aromatics (benzene, toluene, xylenes).

    1. Behr A.Angewandte Homogene Katalyse; Wiley-VCH: Weinheim, 2008; Chapter 28, pp 441–464.
    2. Aresta M.; Dibenedetto A. Dalton Trans. 2007, 2975–2992. - PubMed
    3. Huang K.; Sun C.-L.; Shi Z.-J. Chem. Soc. Rev. 2011, 40, 2435–2452. - PubMed
    4. Baiker A. Appl. Organomet. Chem. 2000, 14, 751–762.
    5. Omae I. Catal. Today 2006, 115, 33–52.
    6. Zevenhoven R.; Eloneva S.; Teir S. Catal. Today 2006, 115, 73–79.
    7. Aresta M., Ed. Carbon Dioxide as Chemical Feedstock; Wiley-VCH: Weinheim, 2010.
    1. Zhang L.; Cheng J.; Ohishi T.; Hou Z. Angew. Chem., Int. Ed. 2010, 49, 8670–8673. - PubMed
    2. Bernhardt S.; Metzger A.; Knochel P. Synthesis 2010, 3802–3810.
    1. Zhang Y.-G.; Riduan S. N. Angew. Chem., Int. Ed. 2011, 50, 6210–6212. - PubMed
    1. Decortes A.; Castilla A. M.; Kleij A. W. Angew. Chem., Int. Ed. 2010, 49, 9822–9837. - PubMed

Publication types

MeSH terms