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. 2012 Jun 1;590(11):2613-28.
doi: 10.1113/jphysiol.2011.224238. Epub 2012 Apr 2.

How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project

Denis Noble  1 , Alan Garny, Penelope J Noble
Affiliations

How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project

Denis Noble et al. J Physiol. .

Abstract

Early modelling of cardiac cells (1960-1980) was based on extensions of the Hodgkin-Huxley nerve axon equations with additional channels incorporated, but after 1980 it became clear that processes other than ion channel gating were also critical in generating electrical activity. This article reviews the development of models representing almost all cell types in the heart, many different species, and the software tools that have been created to facilitate the cardiac Physiome Project.

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Figures

Figure 1
Figure 1. Schematic representation of the Ferranti Mercury computer, a valve-based machine
It had no screen and no graphics. Communication was via punched-hole paper tape.
Figure 2
Figure 2
The Brunsviga Model 20 mechanical calculator (ca. 1910)
See this image and copyright information in PMC

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