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. 2012:2012:645967.
doi: 10.1155/2012/645967. Epub 2012 Mar 5.

Neurological Disorders in Primary Sjögren's Syndrome

Affiliations

Neurological Disorders in Primary Sjögren's Syndrome

Gabriel J Tobón et al. Autoimmune Dis. 2012.

Abstract

Sjögren's syndrome is an autoimmune disease characterized by an autoimmune exocrinopathy involving mainly salivary and lacrimal glands. The histopathological hallmark is periductal lymphocytic infiltration of the exocrine glands, resulting in loss of their secretory function. Several systemic manifestations may be found in patients with Sjögren's syndrome including neurological disorders. Neurological involvement ranges from 0 to 70% among various series and may present with central nervous system and/or peripheral nervous system involvement. This paper endeavors to review the main clinical neurological manifestations in Sjögren syndrome, the physiopathology, and their therapeutic response.

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Figures

Figure 1
Figure 1
Pathophysiological mechanism implicated in the development of central and peripheral nervous system manifestations in primary Sjögren's syndrome.

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