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. 2012:2012:215052.
doi: 10.1155/2012/215052. Epub 2012 Feb 1.

Changes in serum lipids and blood glucose in non diabetic patients with metabolic syndrome after mixed meals of different composition

Adriana Branchi  1 , Adriana Torri, Cristina Berra, Emanuela Colombo, Domenico Sommariva
Affiliations

Changes in serum lipids and blood glucose in non diabetic patients with metabolic syndrome after mixed meals of different composition

Adriana Branchi et al. J Nutr Metab. 2012.

Abstract

Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient composition of the meal elicits different response in patients with (MetS+) and without (MetS-) metabolic syndrome. Research Design and Methods. 50 MetS+ patients and 50 age- and sex-matched MetS- consumed a regular lunch chosen among those more similar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal. Results. Serum triglycerides increased more in MetS+ (35%, 4:30 hours after the meal) than in MetS- (29%), HDL-cholesterol decreased 2 hours after the meal in both groups (-4% and -5%, resp.). Blood sugar similarly increased in both groups (19%, 2 hours after the meal in MetS+ and 17% in MetS-) and plasma insulin increased more and remained high longer in MetS+ (73.5 and 52.3 μU/mL, 2 and 4:30 hours after the meal) than in MetS- (46.7 and 21.6 μU/mL). Difference in nutrient composition of the meal (carbohydrate 57%, fat 28% versus carbohydrate 45%, fat 35%) was not associated with differences in postprandial levels of triglycerides, HDL-cholesterol, glucose, and insulin within each group. Conclusions. As compared with MetS-, MetS+ patients show a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of the meal.

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Figures

Figure 1
Figure 1
Line plots show the postprandial responses of serum lipids, HDL cholesterol, apolipoprotein A-I and B, blood glucose, and insulin in patients with MetS (–⬤–) and without MetS (- -▲- -). Vertical bars are the standard error of the mean. Filled symbols represent significant difference from baseline. *P < 0.05, **P < 0.01, ***P < 0.001 versus patients without MetS.
Figure 2
Figure 2
Line plots show the postprandial responses of serum triglycerides, HDL cholesterol, blood glucose, and insulin in patients on low-fat and on low-carbohydrate diet. (–⬤–) MetS+ low-CHO meal; (- -■- -) MetS+ low-fat meal; (- -◆- -) MetS− low-CHO meal; (- -▲- -) MetS− low-fat diet. Vertical bars are the standard error of the mean. Filled symbols represent significant difference from baseline.
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