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Review
. 2012:2012:784040.
doi: 10.1155/2012/784040. Epub 2012 Feb 16.

NGF, brain and behavioral plasticity

Alessandra Berry  1 , Erika Bindocci, Enrico Alleva
Affiliations
Review

NGF, brain and behavioral plasticity

Alessandra Berry et al. Neural Plast. 2012.

Abstract

Nerve Growth Factor (NGF) was initially studied for its role as a key player in the regulation of peripheral innervations. However, the successive finding of its release in the bloodstream of male mice following aggressive encounters and its presence in the central nervous system led to the hypothesis that variations in brain NGF levels, caused by psychosocial stressor, and the related alterations in emotionality, could be functional to the development of proper strategies to cope with the stressor itself and thus to survive. Years later this vision is still relevant, and the body of evidence on the role of NGF has been strengthened and expanded from trophic factor playing a role in brain growth and differentiation to a much more complex messenger, involved in psychoneuroendocrine plasticity.

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Figures

Figure 1
Figure 1
NGF secretion may exert an inhibitory feedback effect on the aggressive behavior of male mice. The higher NGF release and the hypertrophy of the adrenals, occurring in subordinates male mice, suggest a “regulative loop” involving NGF-mediated increase of glucocorticoids secretion (upon adrenals) acting to enhance a submissive profile.
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