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Review
. 2012 Apr 5;12(5):349-61.
doi: 10.1038/nrc3218.

From genes to drugs: targeted strategies for melanoma

Keith T Flaherty  1 , F Stephen Hodi, David E Fisher
Affiliations
Review

From genes to drugs: targeted strategies for melanoma

Keith T Flaherty et al. Nat Rev Cancer. .

Erratum in

Abstract

The past decade has revealed that melanoma is comprised of multiple subclasses that can be categorized on the basis of key features, including the clinical stage of disease, the oncogenic molecular 'drivers', the anatomical location or the behaviour of the primary lesion and the expression of specific biomarkers. Although exercises in subclassification are not new in oncology, progress in this area has produced both conceptual and clinical breakthroughs, which, for melanoma, are unprecedented in the modern history of the disease. This Review focuses on these recent striking advances in the strategy of molecularly targeted approaches to the therapy of melanoma in humans.

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References

    1. Immunity. 1997 Dec;7(6):885-95 - PubMed
    1. Lancet Oncol. 2010 Feb;11(2):155-64 - PubMed
    1. Pigment Cell Melanoma Res. 2008 Aug;21(4):492-3 - PubMed
    1. Nature. 2006 Jan 19;439(7074):358-62 - PubMed
    1. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):393-7 - PubMed

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