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Multicenter Study
. 2012 May;33(5):470-6.
doi: 10.1086/665318. Epub 2012 Mar 20.

A multicenter study of Clostridium difficile infection-related colectomy, 2000-2006

Amelia M Kasper  1 , Humaa A Nyazee, Deborah S Yokoe, Jeanmarie Mayer, Julie E Mangino, Yosef M Khan, Bala Hota, Victoria J Fraser, Erik R Dubberke; Centers for Disease Control and Prevention Epicenters Program
Affiliations
Multicenter Study

A multicenter study of Clostridium difficile infection-related colectomy, 2000-2006

Amelia M Kasper et al. Infect Control Hosp Epidemiol. 2012 May.

Abstract

Objective: To assess Clostridium difficile infection (CDI)-related colectomy rates by CDI surveillance definitions and over time at multiple healthcare facilities.

Setting: Five university-affiliated acute care hospitals in the United States.

Design and methods: Cases of CDI and patients who underwent colectomy from July 2000 through June 2006 were identified from 5 US tertiary care centers. Monthly CDI-related colectomy rates were calculated as the number of CDI-related colectomies per 1,000 CDI cases, and cases were categorized according to recommended surveillance definitions. Logistic regression was performed to evaluate risk factors for CDI-related colectomy.

Results: In total, 8,569 cases of CDI were identified, and 75 patients underwent CDI-related colectomy. The overall colectomy rate was 8.7 per 1,000 CDI cases. The CDI-related colectomy rate ranged from 0 to 23 per 1,000 CDI episodes across hospitals. The colectomy rate for healthcare-facility-onset CDI was 4.3 per 1,000 CDI cases, and that for community-onset CDI was 16.5 per 1,000 CDI cases (P < .05). There were significantly more CDI-related colectomies at hospitals B and C (P < .05).

Conclusions: The overall CDI-related colectomy rate was low, and there was no significant change in the CDI-related colectomy rate over time. Onset of disease outside the study hospital was an independent risk factor for colectomy.

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Figures

Figure 1
Figure 1
Colectomy rates by hospital over time. There was a significant increase in colectomies over time at hospital A (p=.01)
Figure 2
Figure 2
CDI-related colectomy rates by location of symptom onset.
See this image and copyright information in PMC

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