Clinical research and development of tuberculosis diagnostics: moving from silos to synergy
- PMID: 22476718
- PMCID: PMC3334509
- DOI: 10.1093/infdis/jis194
Clinical research and development of tuberculosis diagnostics: moving from silos to synergy
Abstract
The development, evaluation, and implementation of new and improved diagnostics have been identified as critical needs by human immunodeficiency virus (HIV) and tuberculosis researchers and clinicians alike. These needs exist in international and domestic settings and in adult and pediatric populations. Experts in tuberculosis and HIV care, researchers, healthcare providers, public health experts, and industry representatives, as well as representatives of pertinent US federal agencies (Centers for Disease Control and Prevention, Food and Drug Administration, National Institutes of Health, United States Agency for International Development) assembled at a workshop proposed by the Diagnostics Working Group of the Federal Tuberculosis Taskforce to review the state of tuberculosis diagnostics development in adult and pediatric populations.
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References
-
- Steingart KR, Henry M, Ng V, et al. Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review. Lancet Infect Dis. 2006;6:570–81. - PubMed
-
- Steingart KR, Ng V, Henry M, et al. Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review. Lancet Infect Dis. 2006;6:664–74. - PubMed
-
- Steingart KR, Ramsay A, Pai M. Optimizing sputum smear microscopy for the diagnosis of pulmonary tuberculosis. Expert Rev Anti Infect Ther. 2007;5:327–31. - PubMed
-
- World Health Organization report—global tuberculosis control. Geneva, Switzerland: 2011.
-
- Dorman SE. New diagnostic tests for tuberculosis: bench, bedside, and beyond. Clin Infect Dis. 2010;50(Suppl 3):S173–7. - PubMed
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