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Clinical Trial
. 2012 Dec;14(6):771-6.
doi: 10.1007/s11307-012-0556-0.

P-glycoprotein function at the blood-brain barrier: effects of age and gender

Daniëlle M E van Assema  1 , Mark Lubberink, Ronald Boellaard, Robert C Schuit, Albert D Windhorst, Philip Scheltens, Adriaan A Lammertsma, Bart N M van Berckel
Affiliations
Clinical Trial

P-glycoprotein function at the blood-brain barrier: effects of age and gender

Daniëlle M E van Assema et al. Mol Imaging Biol. 2012 Dec.

Abstract

Purpose: P-glycoprotein (Pgp) is an efflux transporter involved in transport of several compounds across the blood-brain barrier (BBB). Loss of Pgp function with increasing age may be involved in the development of age-related disorders, but this may differ between males and females. Pgp function can be quantified in vivo using (R)-[(11)C]verapamil and positron emission tomography. The purpose of this study was to assess global and regional effects of both age and gender on BBB Pgp function.

Procedures: Thirty-five healthy men and women in three different age groups were included. Sixty minutes dynamic (R)-[(11)C]verapamil scans with metabolite-corrected arterial plasma input curves were acquired. Grey matter time-activity curves were fitted to a validated constrained two-tissue compartment plasma input model, providing the volume of distribution (V (T)) of (R)-[(11)C]verapamil as outcome measure.

Results: Increased V (T) of (R)-[(11)C]verapamil with aging was found in several large brain regions in men. Young and elderly women showed comparable V (T) values. Young women had higher V (T) compared with young men.

Conclusions: Decreased BBB Pgp is found with aging; however, effects of age on BBB Pgp function differ between men and women.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Boxplot of volume of distribution (V T) of (R)-[11C]verapamil for the global cortical brain region for the young, middle aged and elderly groups. Men are represented by dark grey bars, women by light grey bars. Open circles outliers, VT = V T.
See this image and copyright information in PMC

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