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. 2012 May;53(3):543-9.
doi: 10.3349/ymj.2012.53.3.543.

Recent changes in the clinicopathologic features of Korean men with prostate cancer: a comparison with Western populations

Seok-Soo Byun  1 , Sangchul Lee, Sang Eun Lee, Eunsik Lee, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Cheryn Song, Hanjong Ahn, Young Deuk Choi, Jin Seon Cho
Affiliations

Recent changes in the clinicopathologic features of Korean men with prostate cancer: a comparison with Western populations

Seok-Soo Byun et al. Yonsei Med J. 2012 May.

Abstract

Purpose: The aim of this study was to evaluate the recent changes in the clinicopathologic features of prostate cancer in Korea and to compare these features with those of Western populations.

Materials and methods: We retrospectively reviewed the data of 1582 men undergoing radical prostatectomy for clinically localized prostate cancer between 1995 and 2007 at 10 institutions in Korea for comparison with Western studies. The patients were divided into two groups in order to evaluate the recent clinicopathological changes in prostate cancer: Group 1 had surgery between 1995 and 2003 (n=280) and Group 2 had surgery between 2004 and 2007 (n=1302). The mean follow-up period was 24 months.

Results: Group 1 had a higher prostate-specific antigen level than Group 2 (10.0 ng/mL vs. 7.5 ng/mL, respectively; p<0.001) and a lower proportion of biopsy Gleason scores ≤6 (35.0% vs. 48.1%, respectively; p<0.001). The proportion of patients with clinical T1 stage was higher in Group 2 than in Group 1. Group 1 had a lower proportion of organ-confined disease (59.6% vs. 68.6%; p<0.001) and a lower proportion of Gleason scores ≤6 (21.3% vs. 33.0%; p<0.001), compared to Group 2. However, the relatively higher proportion of pathologic Gleason scores ≤6 in Group 2 was still lower than those of Western men, even though the proportion of organ-confined disease reached to that of Western series.

Conclusion: Korean men with prostate cancer currently present better clinicopathologic parameters. However, in comparison, Korean men still show relatively worse pathologic Gleason scores than Western men.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
Kaplan-Meier curve of biochemical recurrence-free survival between the two groups.
See this image and copyright information in PMC

References

    1. Giovannucci E, Platz EA. Epidemiology of prostate cancer. In: Vogelzang NJ, Scardino PT, Shipley WU, Debruyne FMJ, Linehan WM, editors. Comprehensive Textbook of Genitourinary Oncology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2006. pp. 9–22.
    1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277–300. - PubMed
    1. Korea Statistical Information Service. [accessed on 2010 October 30]. Available at: http://www.kostat.go.kr.
    1. Kim KI, Chang HJ, Cho YS, Youn TJ, Chung WY, Chae IH, et al. Current status and characteristics of hypertension control in community resident elderly Korean people: data from a Korean longitudinal study on health and aging (KLoSHa study) Hypertens Res. 2008;31:97–105. - PubMed
    1. http://www.ncc.re.kr. [Accessed March 2012].

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