Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 May;63(3):246-9.
doi: 10.4212/cjhp.v63i3.922.

Should IV Antibiotics Be Administered by Prolonged Infusion?

No authors listed

Should IV Antibiotics Be Administered by Prolonged Infusion?

No authors listed. Can J Hosp Pharm. 2010 May.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mean piperacillin concentrations based on Monte Carlo simulation of 5000 patients in the intensive care unit receiving 3.375 g q6h with 0.5-h infusion (solid black line) or 3.375 g q6h with 3-h infusion (solid grey line). Hatched grey line indicates the sensitive minimum inhibitory concentration break point (16 μg/L) for Enterobacteriaceae.

References

    1. Drusano GL. Antimicrobial pharmacodynamics: critical interactions of ‘bug and drug’. Nat Rev Microbiol. 2004;2(4):289–300. - PubMed
    1. Drusano GL, Preston SL, Hardalo C, Hare R, Banfield C, Andes D, et al. Use of preclinical data for selection of a phase II/III dose for evernimicin and identification of a preclinical MIC breakpoint. Antimicrob Agents Chemother. 2001;45(1):13–22. - PMC - PubMed
    1. Mouton J, Schmitt-Hoffmann A, Shapiro S, Nashed N, Punt NC. Use of Monte Carlo simulations to select therapeutic doses and provisional breakpoints of BAL9141. Antimicrob Agents Chemother. 2004;48(5):1713–1718. - PMC - PubMed
    1. Ariano RE, Nyhlén A, Donnelly JP, Sitar DS, Harding GK, Zelenitsky SA. Pharmacokinetics and pharmacodynamics of meropenem in febrile neutropenic patients with bacteremia. Ann Pharmacother. 2005;39(1):32–38. - PubMed
    1. Zelenitsky S, Ariano R, Harding G, Forrest A. Evaluating ciprofloxacin dosing for Pseudomonas aeruginosa infection by using clinical outcome-based Monte Carlo simulations. Antimicrob Agents Chemother. 2005;49(1):4009–4014. - PMC - PubMed

LinkOut - more resources