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. 2010:2010:bcr04.2009.1757.
doi: 10.1136/bcr.04.2009.1757. Epub 2010 Apr 5.

Melorheostosis and its treatment with intravenous zoledronic acid

Rosemary Jane Hollick  1 , Alison Black, David Reid
Affiliations

Melorheostosis and its treatment with intravenous zoledronic acid

Rosemary Jane Hollick et al. BMJ Case Rep. 2010.

Abstract

We report a case of melorheostosis, a rare bone disorder characterised by mesodermal dysplasia, and its successful and prolonged treatment with the intravenous bisphosphonate zoledronic acid. The middle-aged man presented with pain and swelling of his tibia, which was diagnosed by imaging and bone biopsy as being due to melorheostosis. There was early symptom control after a single infusion of intravenous zoledronic acid. Prolonged symptom relief was accompanied by long-term suppression of the bone resorption marker β cross-laps. We suggest that melorheostosis can be treated with intravenous zoledronic acid and that treatment can be monitored by the use of a specific bone resorption marker.

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Figures

Figure 1
Figure 1
Lateral plain radiograph of right tibia demonstrating a periostial pattern of hyperostosis with a hardened candle wax appearance along the anterior tibial cortex (2003).
See this image and copyright information in PMC

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