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Randomized Controlled Trial
. 2012 Apr 5:12:30.
doi: 10.1186/1471-244X-12-30.

A randomized controlled trial of CBT therapy for adults with ADHD with and without medication

Margaret Weiss  1 , Candice Murray, Michael Wasdell, Brian Greenfield, Lauren Giles, Lily Hechtman
Affiliations
Randomized Controlled Trial

A randomized controlled trial of CBT therapy for adults with ADHD with and without medication

Margaret Weiss et al. BMC Psychiatry. .

Abstract

Background: Previous studies of psychological treatment in adults with ADHD have not controlled for medication status and include either medicated participants or mixed samples of medicated and unmedicated participants. The objective of this study is to examine whether use of medication improves outcome of therapy.

Method: This was a secondary analysis comparing 23 participants randomized to CBT and Dextroamphetamine vs. 25 participants randomized to CBT and placebo. Both patients and investigators were blind to treatment assignment. Two co-primary outcomes were used: ADHD symptoms on the ADHD-RS-Inv completed by the investigator and improvement in functioning as reported by the patient on the Sheehan Disability Scale.

Results: Both groups showed robust improvement in both symptoms and functioning, but the use of medication did not significantly improve outcome over and above use of CBT and placebo.

Conclusion: This study replicates previous work demonstrating that CBT is an effective treatment for ADHD in adults. Within the limits of this pilot, secondary analysis we were not able to demonstrate that medication significantly augments the outcome of CBT therapy for adults with ADHD. The study was funded by GlaxoSmithKline, Clinical Trials Registry #GSK707.

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Figures

Figure 1
Figure 1
Patient Flow.
Figure 2
Figure 2
Treatment Schedule.
Figure 3
Figure 3
ADHD RS-Inv by Time and Treatment.
Figure 4
Figure 4
Sheehan Disability Scale by Time and Treatment.
See this image and copyright information in PMC

References

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