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. 2012:2012:468615.
doi: 10.1155/2012/468615. Epub 2012 Mar 18.

GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach

Florence Delie  1 , Patrick Petignat, Marie Cohen
Affiliations

GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach

Florence Delie et al. J Oncol. 2012.

Abstract

Glucose-regulated protein of 78 kD (GRP78) is a chaperone protein mainly located in the endoplasmic reticulum (ER). This protein is normally present at low levels in adult cells but its expression is triggered by ER stress including glucose deprivation and hypoxia. In tumor cells, it is overexpressed with fraction of protein found at the cell surface. This paper presents the physiology of GRP78 in the context of ovarian cancer and its potential use as drug delivery systems targeting ovarian cancer cell.

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References

    1. Dudek J, Benedix J, Cappel S, et al. Functions and pathologies of BiP and its interaction partners. Cellular and Molecular Life Sciences. 2009;66(9):1556–1569. - PMC - PubMed
    1. Hendershot LM. The ER chaperone BiP is a master regulator of ER function. Mount Sinai Journal of Medicine. 2004;71(5):289–297. - PubMed
    1. Ni M, Lee AS. ER chaperones in mammalian development and human diseases. FEBS Letters. 2007;581(19):3641–3651. - PMC - PubMed
    1. Lee AS. The glucose-regulated proteins: stress induction and clinical applications. Trends in Biochemical Sciences. 2001;26(8):504–510. - PubMed
    1. Dong D, Dubeau L, Bading J, et al. Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible Grp78 promoter resulting in eradication of sizable human tumors. Human Gene Therapy. 2004;15(6):553–561. - PubMed

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