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Comment
. 2012 Apr 6;10(4):349-50.
doi: 10.1016/j.stem.2012.03.004.

Generation of transplantable striatal projection neurons from human ESCs

Malin Parmar  1 , Anders Björklund
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Generation of transplantable striatal projection neurons from human ESCs

Malin Parmar et al. Cell Stem Cell. .
Free article

Abstract

In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease.

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