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doi: 10.1016/j.stem.2012.03.012.
In epigenetic therapy, less is more
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- PMID: 22482500
- DOI: 10.1016/j.stem.2012.03.012
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Comment
In epigenetic therapy, less is more
Cell Stem Cell.
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Free article
Abstract
How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells.
Copyright © 2012 Elsevier Inc. All rights reserved.
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Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells.Cancer Cell. 2012 Mar 20;21(3):430-46. doi: 10.1016/j.ccr.2011.12.029. Cancer Cell. 2012. PMID: 22439938 Free PMC article.
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