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Review
. 2012 Aug;126(2):304-11.
doi: 10.1016/j.ygyno.2012.03.047. Epub 2012 Apr 4.

Susceptibility to cervical cancer: an overview

Antonio Carlos de Freitas  1 , Ana Pavla Almeida Diniz Gurgel, Bárbara Simas Chagas, Eliane Campos Coimbra, Carolina Maria Medeiros do Amaral
Affiliations
Review

Susceptibility to cervical cancer: an overview

Antonio Carlos de Freitas et al. Gynecol Oncol. 2012 Aug.

Abstract

Cervical cancer is the second most common cancer in females worldwide. It is well-established that Human Papillomavirus (HPV) infections play a critical role in the development of cervical cancer. However, a large number of women infected with oncogenic HPV types will never develop cervical cancer. Thus, there are several external environment and genetic factors involved in the progression of a precancerous lesion to invasive cancer. In this review article, we addressed possible susceptible phenotypes to cervical cancer, focusing on host genome and HPV DNA variability, multiple HPV infections, co-infection with other agents, circulating HPV DNA and lifestyle.

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