Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jul 1;430(1-2):86-8.
doi: 10.1016/j.ijpharm.2012.03.039. Epub 2012 Apr 3.

Di-(2-ethylhexyl)-phthalate migration from irradiated poly(vinyl chloride) blood bags for graft-vs-host disease prevention

Marcella Ferri  1 , Federica Chiellini, Giorgio Pili, Luca Grimaldi, Elena Tiziana Florio, Stefania Pili, Francesco Cucci, Giuseppe Latini
Affiliations

Di-(2-ethylhexyl)-phthalate migration from irradiated poly(vinyl chloride) blood bags for graft-vs-host disease prevention

Marcella Ferri et al. Int J Pharm. .

Erratum in

  • Int J Pharm. 2012 Dec;439(1-2):358. Marcella, Ferri [corrected to Ferri, Marcella]; Federica, Chiellini [corrected to Chiellini, Federica]; Giorgio, Pili [corrected to Pili, Giorgio]; Luca, Grimaldi [corrected to Grimaldi, Luca]; Stefania, Pili [corrected to Pili, Stefania]; Francesco, Cucci

Abstract

Irradiation with 20-25 kGy is a process commonly used for sterilizing poly(vinyl chloride) (PVC) medical devices. Moreover, whole blood and blood components undergo additional irradiation with 25-50 Gy to inhibit the proliferative capacity of lymphocytes and reduce the risk of transfusion-associated graft-vs-host disease (GVHD). Di-(2-ethylhexyl)-phthalate (DEHP) plasticized PVC is extensively used for the production of flexible medical devices including blood bags, but since DEHP is not covalently bound to PVC, it tends to migrate and leach out of the medical device, with harmful consequences for the patients. In this study, the effects of different doses of gamma irradiation on DEHP migration from PVC blood bags was investigated using differential scanning calorimetry (DSC) analysis. Our findings indicate that irradiation with 25-100 Gy reduces the ability of DEHP to migrate from the blood bags, and in the case of a primary container a correlation between the doses of gamma ray irradiation was also observed. In particular, a decrease in DEHP leachability was obtained by increasing the dose of gamma ray irradiation.

PubMed Disclaimer