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Clinical Trial
. 2012 Aug;87(8):790-4.
doi: 10.1002/ajh.23205. Epub 2012 Apr 10.

The prognostic significance of lymphopenia in peripheral T-cell and natural killer/T-cell lymphomas: a study of 826 cases from the International Peripheral T-cell Lymphoma Project

Zdravko Mitrovic  1 , Anamarija M Perry, Junji Suzumiya, James O Armitage, Wing Y Au, Bertrand Coiffier, Harald Holte, Elaine S Jaffe, Emili Monserrat, Sandeep K Rajan, Kerry J Savage, Kensei Tobinai, Julie M Vose, Dennis D Weisenburger
Affiliations
Clinical Trial

The prognostic significance of lymphopenia in peripheral T-cell and natural killer/T-cell lymphomas: a study of 826 cases from the International Peripheral T-cell Lymphoma Project

Zdravko Mitrovic et al. Am J Hematol. 2012 Aug.

Abstract

Lymphopenia is a marker of inferior survival in patients with various malignancies. However, the prognostic significance of lymphopenia in peripheral T-cell lymphoma (PTCL) is unclear. We analyzed the prognostic significance of lymphopenia in 826 patients with different types of PTCL and natural killer/T-cell lymphoma (NKTCL) from the International Peripheral T-cell Lymphoma Project. Lymphopenia was defined as an absolute lymphocyte count of less than 1,000 cells per microliter. The overall frequency of lymphopenia was 35.3%, ranging from 21.1% in ALK(+) anaplastic large cell lymphoma (ALCL) to 47.5% in angioimmunoblastic T-cell lymphoma (AITL). Lymphopenia was independently associated with an inferior overall survival (OS) in patients with the lymphoma type of adult T-cell leukemia/lymphoma (ATLL), with a 2-year OS of 15% versus 40% for those without lymphopenia (P < 0.001). Lymphopenia was also an adverse predictor of survival in PTCL, not otherwise specified, but was associated with other unfavorable prognostic factors. A trend toward inferior survival for lymphopenic patients was also observed in AITL, ALK(-) ALCL and extranasal NKTCL lymphoma, whereas no difference in survival was found in nasal NKTCL, ALK(+) ALCL, or enteropathy-associated T-cell lymphoma. In this study, lymphopenia was identified as a new adverse prognostic factor in the lymphoma type of ATLL.

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Conflict of interest statement

Conflict of interest: Nothing to report.

Figures

Figure 1.
Figure 1.
Overall survival (a) and failure-free survival (b) according to the absolute lymphocyte count (ALC) in the lymphoma type of adult T-cell leukemia/ lymphoma
Figure 2.
Figure 2.
Overall survival (a) and failure-free survival (b) according to the absolute lymphocyte count (ALC) in peripheral T-cell lymphoma, not otherwise specified.
See this image and copyright information in PMC

References

    1. Swerdlow S,Campo E,Harris N, et al., editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th ed. Lyon: IARC Press; 2008.
    1. Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 2008;26:4124–4130. - PubMed
    1. Foss FM, Zinzani PL, Vose JM, et al. Peripheral T-cell lymphoma. Blood 2011;117:6756–6767. - PubMed
    1. Ship MA, Harrington DP, Anderson JR et al. A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. N Engl J Med 1993;329:987–994. - PubMed
    1. Ansell SM, Habermann TM, Kurtin PJ, et al. Predictive capacity of the International Prognostic Factor Index in patients with peripheral T-cell lymphoma. J Clin Oncol 1997;15:2296–2301. - PubMed