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. 2012 Jun;83(3):294-8.
doi: 10.3109/17453674.2012.678797. Epub 2012 Apr 11.

Congenital talipes equinovarus: an epidemiological study in Sicily

Vito Pavone  1 , Sebastiano Bianca, Giuseppe Grosso, Piero Pavone, Antonio Mistretta, Maria Roberta Longo, Silvia Marino, Giuseppe Sessa
Affiliations

Congenital talipes equinovarus: an epidemiological study in Sicily

Vito Pavone et al. Acta Orthop. 2012 Jun.

Abstract

Background and purpose: Congenital talipes equinovarus (clubfoot) can present in 2 forms: "syndromic", in which other malformations exist, and the more common "idiopathic" form, where there are no other associated malformations. We analyzed the epidemiology of congenital talipes equinovarus in the Sicilian population, looking for potential etiological factors.

Patients and methods: Among the 801,324 live births recorded between January 1991 and December 2004, 827 cases were registered (560 males; M/F sex ratio: 2.1). Control infants were randomly selected from a historical cohort of live births without any major congenital malformations.

Results: A positive family history of clubfoot, gender, and maternal smoking were found to be risk factors for clubfoot. Patients with clubfoot were born most frequently during the period January-March. No association was found between clubfoot and reproductive history, peri-conceptional maternal drug exposure, maternal education, or ethnicity.

Interpretation: Our findings emphasize the importance of birth defects surveillance programs and their usefulness in investigating potential risk factors.

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Figures

None
Circular histogram showing monthly distribution of new births with congenital clubfoot in Sicily during the period 1991–2004. The length of each black bar represents the frequency. The arrow indicates the mean vector corresponding to February.
See this image and copyright information in PMC

Comment in

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